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Welcome to the ERZOFRI® patient site

ERZOFRI® (paliperidone palmitate) is a long-acting injectable medication for the treatment of adults with schizophrenia or schizoaffective disorder.

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Your ERZOFRI® journey

If you, or someone you care for, have been diagnosed with schizophrenia 
or schizoaffective disorder, ERZOFRI® may offer a path forward.

For many patients, medication is an important part of their treatment plan—it may help manage symptoms, lower the risk of symptoms returning, or reduce the risk of needing a hospital stay. With treatment, many people with schizophrenia and schizoaffective disorder can live fuller, healthier lives.

ERZOFRI® helps simplify starting treatment

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ERZOFRI® provides a unique dosage formulation for a widely used, safe and effective product.

Icon Dose

ERZOFRI® is simple from the start—without the need for a second dose in the first month, which may provide more convenience.

More things you should know about ERZOFRI®

For appropriate patients starting ERZOFRI®

Your healthcare provider will give you ERZOFRI® by injection once a month.

ERZOFRI® slowly releases over time. This helps keep a steady amount
of ERZOFRI® in your body between injections.

ERZOFRI® offers a unique first dosage strength—so your
first dose lasts the whole month

Injection

You will be given a 
single starting dose 
of ERZOFRI®.

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Treatment will continue with an injection at your doctor’s office every month.

Note: Continue to take your prescribed mood stabilizers and antidepressants as directed by your doctor.

ERZOFRI® can be an important first step in your treatment journey—and help all along the way.

Preparing for your next visit

Schedule

At the end of each visit, schedule your next monthly injection appointment before you leave your doctor’s office.

Reminder

Set a calendar reminder for each appointment.

Patient support

Learn more to help you start and stay on track with ERZOFRI®.

ERZOFRI® Assist Program

There are resources and support available that may be able to help you start and stay on track with managing your treatment. If you have questions about available resources, we are here to help. Please call our dedicated ERZOFRI® Assist line at
1-800-548-9765, 9:00 AM-5:00 PM EST.

No enrollment required. 
ERZOFRI® Assist can:
  • Introduce savings and access programs you may qualify for (if eligible) when taking ERZOFRI®
  • Answer common questions about taking ERZOFRI®
  • Refer you to resources provided by third-party organizations that may help you with everyday needs
  • Offer support in English, Spanish, or other languages via translation services
  • Help you learn about possible independent financial support options if you have affordability concerns

$10 Copay Card

Patients with commercial insurance could pay as little as $10 per dose* with the ERZOFRI® Copay Card Program.

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Copay Card

ERZOFRI® Copay Card Program Terms and Conditions

Eligibility Requirements:

Eligibility Criteria: Subject to program limitations and terms and conditions, the ERZOFRI® Copay Card Program, also referred to simply as the ERZOFRI® Copay Card, is open to patients who have a valid prescription for ERZOFRI® and who have commercial or private insurance that covers ERZOFRI®, including state and federal plans commonly referred to as “healthcare exchange plans.” No substitutions for ERZOFRI® are permitted.

  • Eligible patients must be over the age of 18 and have commercial prescription insurance administered through a pharmacy or medical benefit plan.
  • Uninsured patients are NOT eligible to be enrolled in this copay program.
  • This copay program will pay for the out-of-pocket copay payments otherwise due from eligible patients for prescription drug coverage related to ERZOFRI®, up to the program limits.
  • This copay program does not cover any copays or other costs related to medical office visits or administration of ERZOFRI®.
  • There are no income requirements for patients to qualify for this program.
  • This offer is not valid for patients whose coverage for ERZOFRI® is paid for in whole or in part by Medicare, Medicaid, or any other federal or state healthcare program such as VA, TRICARE or DOD.
  • This program is not valid for cash-paying patients.
  • Cash Discount Cards and other non-insurance plans are NOT valid as primary insurance under this program.
  • This program is restricted to residents of the United States.
  • Patients residing in or receiving treatment in certain states may not be eligible.
  • Eligible patients may pay as little as $10 for once-monthly injections of ERZOFRI®.
  • Maximum annual benefit of $8000 per individual applies and out-of-pocket expenses may vary. Patients are responsible for costs above maximum benefit amounts.

Other Terms and Conditions:

  • Patients with managed care requirements (e.g., prior authorization, step edit) must fulfill those requirements before they can be considered for enrollment.
  • To enroll in this program, patients will be required to provide personal information that includes name, home address, email address, phone number, and other information, including prescription and insurance information. This information is needed for Luye Pharma Group Ltd. and its affiliates to enroll you in the ERZOFRI® Copay Card Program. The use of your information will be governed by the Luye Pharma Group Ltd. Privacy Policy.
  • If a patient begins receiving coverage for prescriptions under any federal, state, or government healthcare program (including but not limited to Medicare, Medicaid, TRICARE, Department of Defense, or Veteran Affairs programs), the patient will no longer qualify for this program and must contact the ERZOFRI® Copay Card Program at (844) 463-0375 to stop participation in this program.
  • If the pharmacy cannot process the ERZOFRI® Copay Card, patients may still be able to receive a rebate by submitting a rebate request. Rebate requests must be submitted within 180 days of the date of service.

Additional Limitations:

The ERZOFRI® Copay Card is intended for the benefit of patients, not their insurance plans, pharmacy benefit managers, or other third parties (“Plan Administrators”). Patients whose commercial insurance plans or plan sponsors implement the following types of programs may not be eligible for the ERZOFRI® Copay Card, or have a reduced annual maximum ERZOFRI® Copay Card benefit:

  • Programs that do not apply ERZOFRI® Copay Card payments to satisfy patient out-of-pocket cost sharing amounts (e.g., accumulator programs); or
  • Programs that require the patient’s use of the ERZOFRI® Copay Card as a condition of the plan waiving some or all of otherwise applicable patient out-of-pocket cost sharing amounts (e.g., maximizer programs).

If you believe your commercial insurance plan may have such programs in place, please call (844) 463-0375. Plan Administrators are prohibited from applying for, or assisting with, the enrollment of patients for the ERZOFRI® Copay Card benefits. The patient or their legal representative must personally enroll in the ERZOFRI® Copay Card to be eligible for benefits.

This program is not health insurance. Void if copied, transferred, purchased, altered, or traded and where prohibited and restricted by law. The program is not transferable. No substitutions are permitted. The program form may not be sold, purchased, traded, or counterfeited. Void if reproduced. The program benefit cannot be combined with any other financial assistance program, free trial, discount, prescription savings card, or other offers.

This program is managed by Paysign on behalf of Luye Pharma Group Ltd. and Luye Pharma Group Ltd. reserves the right to make eligibility determinations, to set program benefit maximums, to monitor participation, and to change, rescind, revoke, or discontinue this program at any time without notice. This program expires December 31, 2025.

If you have any questions regarding this program, your eligibility, or benefits, or if you wish to discontinue your participation, please call (844) 463-0375, Monday-Friday, 8 AM-8 PM EST, excluding holidays.

For the Patient:

As a patient, you must not seek reimbursement for the value received from this ERZOFRI® Copay Card from any third-party payers, including a flexible spending account or healthcare savings account. Participating in this program means that you acknowledge that you are eligible for this program and agree to comply with the terms and conditions. You are also ensuring you comply with any required disclosure regarding your participation in this program to your insurance carrier or pharmacy benefit manager. The ERZOFRI® Copay Card offer must be presented along with your valid ERZOFRI® prescription and your primary insurance card to participate in this program.

Restrictions may apply. Offer subject to change or discontinuation without notice. This is not health insurance. This program is for eligible Commercially Insured Patients only. Uninsured or cash-paying patients are not eligible for this copay program.

You, the patient, may pay as little as $10 once monthly for your ERZOFRI® injections. Your maximum program assistance per prescription and annual benefit limits per patient apply and out-of-pocket expenses may vary.

For the Pharmacist:

When you apply for this program, you confirm that ERZOFRI® is being provided to an eligible commercially insured patient according to the specified terms and conditions, and the pharmacy has not, and will not, submit a claim for reimbursement under any federal, state, or other government program for this prescription.

For patients with commercial insurance, first submit the claim to the primary third-party payer. Afterward, send the remaining balance to Pharmacy Data Management, Inc. (PDMI) as a secondary payer coordination of benefits (COB) with patient responsibility and a valid other coverage code (e.g., 08). If the primary claim is denied by the insurer due to a prior authorization (PA) requirement, please initiate the PA process to assist your patient in saving on prescriptions for ERZOFRI®.

For any questions, please contact the copay support program line at (844) 463-0375, Monday-Friday, 8AM-8PM EST.

Please see full Prescribing Information for ERZOFRI®, including Boxed WARNING.

*Eligibility criteria and maximums apply.

Resources for you

As you navigate your treatment journey, you are not alone. The following organizations are here and can provide you with additional information about living with schizophrenia and schizoaffective disorder. Click the buttons below to learn more:

National Alliance
on Mental Illness

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National Council for
Mental Wellbeing®

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Mental Health
America®

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Schizophrenia &
Psychosis Action
Alliance™

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Substance Abuse and
Mental Health Services
Administration

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Veterans Crisis Line

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Person
Help with government insurance coverage and costs

To inquire about Medicare/Medicaid eligibility, call 1-800-MEDICARE (1-800-633-4227) or check with your state for Medicaid eligibility.

INDICATIONS
What is ERZOFRI® (paliperidone palmitate)?

ERZOFRI is a prescription medicine given by injection by a healthcare provider and used to treat:

  • schizophrenia in adults
  • schizoaffective disorder in adults either alone or with other medicines such as mood stabilizers or antidepressants

It is not known if ERZOFRI is safe and effective in children.

IMPORTANT SAFETY INFORMATION FOR ERZOFRI
ERZOFRI may cause serious side effects, including:

Increased risk of death in elderly people with dementia-related psychosis. ERZOFRI increases the risk of death in elderly people who have lost touch with reality (psychosis) due to confusion and memory loss (dementia). ERZOFRI is not for the treatment of people with dementia-related psychosis.

Do not receive ERZOFRI if you are allergic to paliperidone, risperidone, or any of the ingredients in ERZOFRI.

What are the possible serious side effects of ERZOFRI?

Cardiovascular problems (including stroke) in elderly people with dementia-related psychosis that can lead to death.

Neuroleptic Malignant Syndrome (NMS) a serious condition that can lead to death. Call your healthcare provider right away or go to your nearest emergency room right away if you get any of the following signs or symptoms:

  • high fever
  • stiff muscles
  • confusion
  • sweating
  • changes in your breathing, pulse, heart rate, or blood pressure

Problems with your heartbeat. These heart problems can cause death. Call your healthcare provider right away if you get any of these symptoms:

  • passing out or feeling like you will pass out
  • dizziness
  • feeling as if your heart is pounding or missing beats

Uncontrolled body movements (tardive dyskinesia). ERZOFRI may cause movements that you cannot control in your face, tongue, or other body parts. Tardive dyskinesia may not go away, even if you stop taking ERZOFRI. Tardive dyskinesia may also start after you stop taking ERZOFRI.

Problems with your metabolism such as:

High blood sugar (hyperglycemia) and diabetes. Increases in blood sugar can happen in some people who are treated with ERZOFRI. Extremely high blood sugar can lead to coma or death. If you have diabetes or risk factors for diabetes such as being overweight, or a family history of diabetes, your healthcare provider should check your blood sugar before you start treatment and during your treatment with ERZOFRI.
Call your healthcare provider if you get any of these symptoms of high blood sugar during treatment with ERZOFRI:
  • feel very thirsty
  • feel very hungry
  • feel sick to your stomach
  • need to urinate more than usual
  • feel weak or tired
  • feel confused, or your breath smells fruity
Increased fat levels (cholesterol and triglycerides in your blood). Your healthcare provider may check your cholesterol and triglyceride levels during treatment with ERZOFRI.
Weight gain. You and your healthcare provider should check your weight regularly during treatment with ERZOFRI.

Decreased blood pressure (orthostatic hypotension) and fainting. You may feel lightheaded or faint when you rise too quickly from a sitting or lying position.

Falls. ERZOFRI may make you sleepy or dizzy, may cause a decrease in your blood pressure when changing position (orthostatic hypotension), and can slow your thinking and motor skills which may lead to falls that can cause fractures or other injuries.

Low white blood cell counts. Your healthcare provider may do blood tests during treatment with ERZOFRI.

Increased prolactin levels in your blood (hyperprolactinemia). ERZOFRI may cause a rise in the blood levels of a hormone called prolactin that may cause side effects including missed menstrual periods, a reversible reduction in fertility in females who are able to become pregnant, leakage of milk from the breasts, development of breasts in men, or problems with erection.

Sleepiness, drowsiness feeling tired, difficulty thinking and doing normal activities.

Seizures (convulsions).

Difficulty swallowing that can cause food or liquid to get into your lungs.

Prolonged or painful erection lasting more than 4 hours (priapism). Call your healthcare provider or go to your nearest emergency room right away if you have an erection that lasts more than 4 hours.

Problems with control of your body temperature so that you feel too warm.

Before taking ERZOFRI, tell your healthcare provider about all of your medical conditions including if you:

  • have never taken paliperidone or risperidone before
  • have had neuroleptic malignant syndrome (NMS)
  • have or had heart problems, including heart attack, heart failure, abnormal heart rhythm, or long QT syndrome
  • have or had low levels of potassium or magnesium in your blood
  • have or had uncontrolled movements of your tongue, face, mouth or jaw (tardive dyskinesia)
  • have or had kidney or liver problems
  • have or had high blood sugar, diabetes or have a family history of diabetes
  • have or had high levels of total cholesterol, LDL cholesterol, or triglycerides, or low levels of HDL cholesterol
  • have Parkinson’s disease or a type of dementia called Lewy Body Dementia
  • have or had problems with dizziness or fainting or are being treated for high blood pressure
  • have or had a low white blood cell count
  • have or had seizures or epilepsy
  • are pregnant or plan to become pregnant. It is not known if ERZOFRI will harm your unborn baby.
If you become pregnant during treatment with ERZOFRI, talk to your healthcare provider about registering with the National Pregnancy Registry for Atypical Antipsychotics. You can register by calling 1-866-961-2388 or visit https://womensmentalhealth.org/clinical-and-research-programs/pregnancyregistry/.
Babies born to women who are treated with ERZOFRI during their third trimester of pregnancy may experience symptoms such as tremors, irritability, excessive sleepiness, eye twitching, muscle spasms, decreased appetite, difficulty breathing, or abnormal movement of arms and legs. Let your healthcare provider know if these symptoms occur.
  • are breastfeeding or plan to breastfeed. ERZOFRI can pass into your breastmilk.
Talk to your healthcare provider about the best way to feed your baby if you receive ERZOFRI.

Tell your healthcare provider about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements. ERZOFRI and certain other medicines may affect each other causing possible serious side effects or affect the way each other works. Know the medicines you take. Keep a list of them to show to your healthcare provider or pharmacist when you get a new medicine.

The most common side effects of ERZOFRI include:

  • injection site reactions
  • sleepiness or drowsiness
  • dizziness
  • feeling restless or like you need to move
  • abnormal muscle movements including tremor (shaking), shuffling, uncontrolled involuntary movements, and abnormal movements of your eyes

Tell your healthcare provider if you have any side effect that bothers you or does not go away. These are not all of the possible side effects of ERZOFRI. Call your doctor for medical advice about side effects. You may report side effects to FDA at www.fda.gov/medwatch or call 1-800-FDA-1088.

Please click here to read the full Prescribing Information, including BOXED WARNING, for ERZOFRI and discuss any questions you have with your healthcare professional.

Icon plus
IMPORTANT SAFETY INFORMATION FOR ERZOFRI
ERZOFRI may cause serious side effects, including:

Increased risk of death in elderly people with dementia-related psychosis. ERZOFRI increases the risk of death in elderly people who have lost touch with reality (psychosis) due to confusion and memory loss (dementia). ERZOFRI is not for the treatment of people with dementia-related psychosis.

Do not receive ERZOFRI if you are allergic to paliperidone, risperidone, or any of the ingredients in ERZOFRI.

What are the possible serious side effects of ERZOFRI?

Cardiovascular problems (including stroke) in elderly people with dementia-related psychosis that can lead to death.

Neuroleptic Malignant Syndrome (NMS) a serious condition that can lead to death. Call your healthcare provider right away or go to your nearest emergency room right away if you get any of the following signs or symptoms:

  • high fever
  • stiff muscles
  • confusion
  • sweating
  • changes in your breathing, pulse, heart rate, or blood pressure
Problems with your heartbeat. These heart problems can cause death. Call your healthcare provider right away if you get any of these symptoms:
  • passing out or feeling like you will pass out
  • dizziness
  • feeling as if your heart is pounding or missing beats

Uncontrolled body movements (tardive dyskinesia). ERZOFRI may cause movements that you cannot control in your face, tongue, or other body parts. Tardive dyskinesia may not go away, even if you stop taking ERZOFRI. Tardive dyskinesia may also start after you stop taking ERZOFRI.

Problems with your metabolism such as:

High blood sugar (hyperglycemia) and diabetes. Increases in blood sugar can happen in some people who are treated with ERZOFRI. Extremely high blood sugar can lead to coma or death. If you have diabetes or risk factors for diabetes such as being overweight, or a family history of diabetes, your healthcare provider should check your blood sugar before you start treatment and during your treatment with ERZOFRI.
  Call your healthcare provider if you get any of these symptoms of high blood sugar during treatment with ERZOFRI:
  • feel very thirsty
  • feel very hungry
  • feel sick to your stomach
  • need to urinate more than usual
  • feel weak or tired
  • feel confused, or your breath smells fruity
Increased fat levels (cholesterol and triglycerides in your blood). Your healthcare provider may check your cholesterol and triglyceride levels during treatment with ERZOFRI.
Weight gain. You and your healthcare provider should check your weight regularly during treatment with ERZOFRI.
Decreased blood pressure (orthostatic hypotension) and fainting. You may feel lightheaded or faint when you rise too quickly from a sitting or lying position.

Falls. ERZOFRI may make you sleepy or dizzy, may cause a decrease in your blood pressure when changing position (orthostatic hypotension), and can slow your thinking and motor skills which may lead to falls that can cause fractures or other injuries.

Low white blood cell counts. Your healthcare provider may do blood tests during treatment with ERZOFRI.

Increased prolactin levels in your blood (hyperprolactinemia). ERZOFRI may cause a rise in the blood levels of a hormone called prolactin that may cause side effects including missed menstrual periods, a reversible reduction in fertility in females who are able to become pregnant, leakage of milk from the breasts, development of breasts in men, or problems with erection.

Sleepiness, drowsiness feeling tired, difficulty thinking and doing normal activities.

Seizures (convulsions).

Difficulty swallowing that can cause food or liquid to get into your lungs.

Prolonged or painful erection lasting more than 4 hours (priapism). Call your healthcare provider or go to your nearest emergency room right away if you have an erection that lasts more than 4 hours.

Problems with control of your body temperature so that you feel too warm.

Before taking ERZOFRI, tell your healthcare provider about all of your medical conditions including if you:

  • have never taken paliperidone or risperidone before
  • have had neuroleptic malignant syndrome (NMS)
  • have or had heart problems, including heart attack, heart failure, abnormal heart rhythm, or long QT syndrome
  • have or had low levels of potassium or magnesium in your blood
  • have or had uncontrolled movements of your tongue, face, mouth or jaw (tardive dyskinesia)
  • have or had kidney or liver problems
  • have or had high blood sugar, diabetes or have a family history of diabetes
  • have or had high levels of total cholesterol, LDL cholesterol, or triglycerides, or low levels of HDL cholesterol
  • have Parkinson’s disease or a type of dementia called Lewy Body Dementia
  • have or had problems with dizziness or fainting or are being treated for high blood pressure
  • have or had a low white blood cell count
  • have or had seizures or epilepsy
  • are pregnant or plan to become pregnant. It is not known if ERZOFRI will harm your unborn baby.
If you become pregnant during treatment with ERZOFRI, talk to your healthcare provider about registering with the National Pregnancy Registry for Atypical Antipsychotics. You can register by calling 1-866-961-2388 or visit http://womensmentalhealth.org/clinical-and-research-programs/pregnancyregistry/.
Babies born to women who are treated with ERZOFRI during their third trimester of pregnancy may experience symptoms such as tremors, irritability, excessive sleepiness, eye twitching, muscle spasms, decreased appetite, difficulty breathing, or abnormal movement of arms and legs. Let your healthcare provider know if these symptoms occur.
  • are breastfeeding or plan to breastfeed. ERZOFRI can pass into your breastmilk.
Talk to your healthcare provider about the best way to feed your baby if you receive ERZOFRI.

Tell your healthcare provider about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements. ERZOFRI and certain other medicines may affect each other causing possible serious side effects or affect the way each other works. Know the medicines you take. Keep a list of them to show to your healthcare provider or pharmacist when you get a new medicine.

The most common side effects of ERZOFRI include:

  • injection site reactions
  • sleepiness or drowsiness
  • dizziness
  • feeling restless or like you need to move
  • abnormal muscle movements including tremor (shaking), shuffling, uncontrolled involuntary movements, and abnormal movements of your eyes
Tell your healthcare provider if you have any side effect that bothers you or does not go away. These are not all of the possible side effects of ERZOFRI. Call your doctor for medical advice about side effects. You may report side effects to FDA at www.fda.gov/medwatch or call 1-800-FDA-1088.

Please click here to read the full Prescribing Information, including BOXED WARNING, for ERZOFRI and discuss any questions you have with your healthcare professional.